Bursting Dynamics of Spiking Neural Network Induced by Active Extracellular Medium

We propose a mathematical model of spiking neural network (SNN) that interacts with an active extracellular field formed by the brain matrix (ECM). The SNN exhibits irregular dynamics induced constant noise drive. Following neurobiological facts, neuronal firing leads to production ECM occupies space. In turn, components can modulate signaling and synaptic transmission, for example, through effect so-called scaling. By simulating model, we discovered ECM-mediated regulation activity promotes spike grouping into quasi-synchronous population discharges called bursts. investigated how parameters, particularly strengths influence on may facilitate bursting increase degree synchrony.